Correction: Systemic Complement Activation in Age-Related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
همراهی پلی‌مورفیسم p.Gly119Arg ژن CFI در مبتلایان به بیماری دژنراسیون ماکولای وابسته به سن در جمعیت ساکن در شهر تهران
Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and is characterized by progressive degeneration of the retinal pigment epithelium and secondary photoreceptor loss, resulting in visual loss. Etiological research suggests that age related macular degeneration is a complex disease, caused by the interactions of several genetic and enviro...
متن کاملAge-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver ...
متن کاملSystemic complement activation in central serous chorioretinopathy
PURPOSE A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In age-related macular degeneration, a disease that shows clinical features that overlap with CSC, both genetic risk factors and systemic activation of the complement system have previously been found. In this case-control study, we asse...
متن کامل[The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis].
The wall of blood vessels including those in choroids may be harmed by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic, and genetic impacts (risk factors), which may trigger a protracted response, the so-called host defense response. As a consequence, pathological changes resulting in vascular injury (e. g. atherosclerosis, age-related macular dege...
متن کاملImpact of the Common Genetic Associations of Age-Related Macular Degeneration upon Systemic Complement Component C3d Levels
Age-related macular degeneration (AMD) is a common condition that leads to severe vision loss and dysregulation of the complement system is thought to be associated with the disease. To investigate associations of polymorphisms in AMD susceptibility genes with systemic complement activation, 2655 individuals were genotyped for 32 single nucleotide polymorphisms (SNPs) in or near 23 AMD associat...
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ورودعنوان ژورنال:
- PLoS ONE
دوره 3 شماره
صفحات -
تاریخ انتشار 2008